Policosanol is the generic term used for a mixture of long-chain primary aliphatic saturated alcohols. These alcohols are derived from the waxes of such plants as sugar cane (Saccharum officinarium) and yams (e.g. Dioscorea opposita). They are also found in beeswax. Policosanol may reduce total serum cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels in some. It is a dietary supplement made of medium-chain alcohols extracted from sugar cane. In both clinical and animal studies, Policosanol has been shown to significantly reduce levels of low-density-lipoprotein (LDL) cholesterol and total cholesterol while increasing levels of high-density-lipoprotein (HDL) cholesterol.
Moreover, Policosanol has favorable effects on intermittent claudication, possibly due to its effects on platelet aggregation and endothelial function. There is preliminary evidence that it can reduce platelet aggregation in both healthy and hypercholesterolemic individuals and that it may be of benefit in individuals with intermittent claudication. It may boost energy and enhance sexual performance. Clinical trials indicate that Policosanol may have applications in the treatment of familial (type II) diabetes-related hypercholesterolemia, as well as intermittent claudication. It is a relatively nontoxic and useful agent for reducing LDL and total cholesterol in patients with type 2 or diabetes-related hypercholesterolemia. Long-term use may increase levels of HDL cholesterol. Policosanol has also been associated with lower improved coronary artery health. In clinical studies, Policosanol has demonstrated anti-inflammatory, antiviral, and neuroprotective properties.
References:
Medscape Today. http://www.medscape.com/viewarticle/456944
PDR Health. http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pol_0207.shtml
http://www.policosanol.net/
