Regular Retail: $21.95GABA is the major inhibitory neurotransmitter in the brain and is active at 20% of CNS synapses. As an inhibitory mediator in the brain, GABA, via its neuronal A receptor, inhibits neurons by causing an influx of chloride ions. The anxiolytic, muscle relaxant, and sedative effects of the benzodiazepines, e.g. Librium and Valium, rely upon the facilitation of this chloride influx initiated by GABA. There is evidence that anxiety and panic disorders are associated with excessive neuronal activity consequent to a decrease in GABA's function as an inhibitory mediator. The adverse psychological signs associated with premenstrual syndrome may be due to a dysregulated sensitivity of GABA receptors. GABA also stimulates human growth hormone (HGH) secretion. Studies with oral administration of sodium valproate (an enhancer of endogenous GABA activity) and the muscle relaxant Baclofen (an agonist of the GABA B receptor) demonstrate their ability to stimulate increased HGH levels.
Theanine (glutamic acid gamma-ethylamide) an amino acid derivative found naturally in tea (Camellia sinensis) is also recognized as having calming properties. Human studies have demonstrated that dietary theanine supplementation increases alpha wave activity, fostering a state of alert relaxation. Animal studies have also shown that administration of theanine regulates brain serotonin concentration by affecting either serotonin synthesis or degradation in the brain. It has been hypothesized that serotonin facilitates general and conditioned anxiety at the level of medial temporal lobe structures. Although the calming effect of this tea component may seem contradictory to the stimulatory properties of tea's caffeine content, research suggests that theanine exerts an antagonistic effect on caffeine's stimulatory action.
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