NADH is a natural substance found in most life forms and is necessary for energy production. NADH is the abbreviation used for Nicotinamide Adenine Dinucleotide, one of the most important coenzymes in the human brain and body. There is very preliminary evidence suggesting that NADH might be useful in Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease. It is considered to be important coenzymes needed to produce the energy necessary to sustain life.
Researches show that NADH may stimulate endogenous dopamine biosynthesis and have led to its experimental use in Parkinson's disease. NAD’s reduced form (NADH) has been studied as a way to increase natural dopamine production to maintain healthy levels. Supplementing with NAD also may spare tryptophan in the body from being used for NADH production, making this essential amino acid more available for the production of the neurotransmitter serotonin. A deficiency in serotonin may be associated with certain mood problems.
Most Parkinson's disease treatments palliate symptoms by increasing nigrostriatal dopaminergic tone. A unique strategy for accomplishing this pharmacological end-point proposes using NADH to boost endogenous dopamine production, since it indirectly supplies reducing equivalents to the rate-limiting, tyrosine hydroxylase-catalysed step of dopamine synthesis. Support for using NADH in Parkinson’s disease treatment includes claims that NADH stimulates tyrosine hydroxylase and dopamine biosynthesis in tissue culture and humans, as well as case series associating intravenous and oral NADH administration with Parkinson's disease rating scale improvements.
References:
Swerdlow RH, Center for the Study of Neurodegenerative Diseases, University of Virginia. http://www.biopsychiatry.com/nadh.htm
PDR Health. http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/nad_0179.shtml
J. South. http://www.smart-drugs.net/ias-NADH.htm
NowFoods. http://www.nowfoods.com/index.php?action=itemdetail&item_id=12427
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