Diosmin and Hesperidin are used widely in Europe for decreasing the appearance of varicose veins and spider veins, and also hemmorhoids. Hesperidin is the predominant flavonoid in lemons and oranges. The peel and membranous parts of these fruits have the highest hesperidin concentrations. Hesperidin is classified as a citrus bioflavonoid. Hesperidin, Diosmin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P.
Like almost everything else in our bodies, our veins are susceptible to deterioration with age, especially if we have a poor diet or inadequate exercise. This is particularly true of the veins in our legs, which have the difficult job of conducting blood upward against gravity's relentless pull. The movements of the legs act as a pump to push the blood upward while flimsy valves stop gravity from pulling it back down. However, over time these valves often begin to fail and the blood then begins to pool in the deep veins of the leg, stretching the vein wall and injuring its lining. This situation is called venous insufficiency.
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